NK cells of mice phagocytose hMSCs
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چکیده
منابع مشابه
Immature Dendritic Cells Phagocytose Apoptotic Cells
Dendritic cells, but not macrophages, efficiently phagocytose apoptotic cells and cross-present viral, tumor, and self-antigens to CD8 1 T cells. This in vitro pathway corresponds to the in vivo phenomena of cross-priming and cross-tolerance. Here, we demonstrate that phagocytosis of apoptotic cells is restricted to the immature stage of dendritic cell (DC) development, and that this process is...
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The transmembrane protein tyrosine phosphatase CD45 is differentially required for the development and function of B, T, and NK cells, with mice partially deficient for CD45 having a significant inhibition of T cell, but not NK or B cell, development. CD45-mediated signaling has also been implicated in the development of intrathymic, but not extrathymic, intestinal intraepithelial T lymphocytes...
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Natural killer (NK) cells play a crucial role in regulating immune functions. Few studies have characterized canine NK cells. We previously demonstrated that canine peripheral blood lymphocytes (PBLs) with a low surface CD5 density (CD5lo) are considered a critical NK population. Natural killer cells in most mammals do not express T-cell markers, but canine CD5lo cells express surface molecules...
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To investigate the intrinsic effect of IL-15 expression on CD8 responses we generated IL-15-deficient OT1 TCRtransgenic mice. These mice died surprisingly at around six months of age exhibiting grossly enlarged lymph nodes, spleens and thymi. The affected organs harbored mainly CD8+ T cells that were low for MHC class I, expressed CD25 and CD24 as well as the co-stimulatory receptors CD28, ICOS...
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Cell-mediated immune processes play a prominent role in the clinical manifestations of syphilis, a sexually transmitted disease of humans caused by spirochetal bacterium Treponema pallidum. The immune cell type that initiates the early immune response to T. pallidum thus far has not been identified. However, dendritic cells (DCs) are the first immune-competent cells to encounter antigens within...
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ژورنال
عنوان ژورنال: Hepatology
سال: 2013
ISSN: 0270-9139
DOI: 10.1002/hep.26451